2014 Colloquium on the Biology of Aging at the MBL – Public Agenda

Thursday, August 21 – Friday, August 22, 2014
Sponsored by The Lawrence Ellison Foundation
and the Marine Biological Laboratory
NEW Ellison logo

Thursday, August 21 – Friday, August 22, 2014
MBL’s Lillie Auditorium

Thursday, August 21, 2014
8:45–9:00 Introductions
9:00–9:30 Cellular Senescence and Aging
Judith Campisi, Buck Institute for Research on Aging / LBNL (1998 Senior Scholar)
9:30–10:00 Initiation of Cellular Senescence
Steve Elledge, Harvard Medical School (1998 Senior Scholar)
10:00–10:30 Organelle Deterioration with Age: The Limits of an Interconnected Cellular System
Dan Gottschling, Fred Hutchinson Cancer Research Center (1998 Senior Scholar)
10:30–11:00 Break
11:00–11:30 Telomeres and DNA Damage
Titia de Lange. Rockefeller University (1999 Senior Scholar)
11:30–12:00 PM Regulation of Telomeres and Cell Proliferation in Aging
Victoria Lundblad, Salk Institute (2001 Senior Scholar)
12:00–12:30 PM Rejuvenation Mechanisms During Germ Cell Formation
Angelika Amon, MIT (2012 Senior Scholar)
12:30–1:45 Lunch
1:45–2:15 NAD+ and Sirtuins in Mammalian Aging
Leonard Guarente, MIT (1998 Senior Scholar)
2:15–2:45 Genes that Control Aging in C. elegans
Cynthia Kenyon, Univ. of California San Francisco (1998 and 2002 Senior Scholar)
2:45–3:15 Genetic Mechanisms of Exceptional Aging and Stress Resistance
Steve Austad, University of Alabama, Birmingham (1999 Senior Scholar)
Friday, August 22, 2014
9:00 – 9:30 Enhanced Longevity Associated with Altered Ribosome Function
Brian Kennedy, Buck Institute for Research on Aging (2012 Senior Scholar)
9:30 – 10:00 PGC1 Coactivators and the Control of Oxidative Metabolism and Disease
Bruce Spiegelman, Dana-Farber Cancer Institute (2006 Senior Scholar)
10:00 – 10:30 Genetics of Aging and Xenobiotic Stress Resistance in C. elegans
Gary Ruvkun, Mass. General Hospital, Harvard Medical School (1998 Senior Scholar)
10:30 – 11:00 Break
11:00 – 11:30 Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation
Tom Rando, Stanford (2004 Senior Scholar)
11:30 – 12:00 Aging and Reprogramming: a Two-way Street
Anne Brunet, Stanford (2009 Senior Scholar)
12:00 – 12:30 Rejuvenation of Muscle Stem Cells Restores Strength to Injured Aged Muscles
Helen Blau, Stanford (2001 Senior Scholar)
12:30 – 1:45 Lunch
1:45 – 2:15 Genes and Pathways that Modulate Neural Decline with Age
Nancy Bonini, Univ. of Pennsylvania (2009 Senior Scholar)
2:15 – 2:45 Does Complement-Mediated Synapse Elimination Drive Cognitive Decline in the Aging Brain?
Ben Barres, Stanford (2011 Senior Scholar)
2:45 – 3:15 Aging, Circadian Rhythms, and Sleep
Michael Rosbash, Brandeis (2010 Senior Scholar)
8:00 PM
7th Annual Joshua Lederberg Lecture

Introduction by Gerald Weissmann, M.D.
Susan Lindquist, MIT/Whitehead Institute
“Cellular Quality Control Mechanisms and Neurodegenerative Disease”
Lillie Auditorium