National Xenopus Resource at MBL Innovates New Way to Study Proteins

July 16th, 2014 @   - 

Proteomics, the study of large groups of proteins, can enhance our understanding of a wide range of organisms, with applications in medicine and developmental biology. Such analyses traditionally require a complete genome for the organism being studied in order to obtain a reference set of proteins. However, many organisms that hold potential for proteomic analysis do not yet have a completely sequenced and well-interpreted genome because the costs, in terms of both time and money, can be prohibitive. Xenopus laevis, the African clawed frog, is one such species.

A collaborative study between scientists at Harvard Medical School and the MBL’s National Xenopus Resource (NXR) and Bell Center for Regenerative Biology & Tissue Engineering, published last week in Current Biology, has found a work-around. Instead of relying on DNA, researchers used mRNA sequences to more efficiently create a reference database that can be used for proteomic analysis of Xenopus. Read more…

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