University of Dundee, Ph.D., 1983-1986
Britannia Royal Naval College, 1982-1983
University of Dundee, B.Sc., 1978-1982
Investigating the role played by calcium ions in the signal transduction pathways orchestrating embryonic development.
Calcium signaling is studied through the use of aequorins, a group of bioluminescent proteins. They can either be microinjected or transfected into cells, without disturbing function or development. The pattern of luminescence that is emitted by an aequorin-loaded cell, tissue or embryo, reveals changing patterns and levels of free calcium. Dr Miller is currently studying the role of calcium signaling in fertilization, segregation, cytokinesis, gastrulation and segmentation in zebrafish, and in neural induction in Xenopus. His work also focuses on exploring the calcium-sensitive target elements interacting with both intracellular and intercellular calcium signals – such as cytoskeletal components, morphogenic protein secretions, and localized developmental gene expression via calcium-sensitive transcription factors. A second area of interest is to elucidate the structures and mechanisms of activation of receptor-activated calcium channels in the plasma membrane of non-excitable animal cells. This is being done by targeting aequorins to specific compartments and locations within cells. A third area of research is the development of microscopy and image processing techniques required to collect and visualize ultra-low levels of photon emission from living cells and embryos.
Dr. Miller is Director of the Joint Universities Summer Teaching Laboratory (JUSTL) program, which is an eight week intensive research experience for postgraduate students at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, USA. Students will attend lectures and seminars, undergo training, and conduct individual research projects under the guidance of the JUSTL Director as well as leading MBL Summer Scientist mentors drawn from institutions from around the world.
Andrew L. Miller, Professor
Calcium Aequorin Imaging Lab
Division of Life Science
The Hong Kong University of Science and Technology
Clear Water Bay
Kowloon, Hong Kong SAR
Telephone: (852) 2358 8631