Laboratory of Shinya Inoué

Shinya InouéResearch Staff: Robert Knudson, Gwen Szent-Gyorgyi

Administrative Staff: Jane MacNeil – jmacneil@mbl.edu

Contact: Tel: 508 289-7382

This laboratory pursues studies of the molecular mechanism and control of mitosis, cell division, and cell morphogenesis, with emphasis on biophysical studies made directly on single living cells, especially developing eggs in marine invertebrates. Development of biophysical instrumentation and methodology, such as the centrifuge polarizing microscope, high-extinction polarization optical and video microscopy, digital image processing techniques including dynamic sterioscopic imaging, and exploration of their underlying theory are an integral part of the laboratory’s effort.

Education:

1951 Ph.D. Biology, Princeton University

1950 M.A. Biology, Princeton University

1944 Rigakushi Zoology, Tokyo University

Honors:

National Academy of Sciences, Elected, April 1993

Recent Publications:

Inoué, S. 2002. Polarization microscopy. In j. Lippincott-Schwartz, ed., Current Protocols in Cell Biology, Suppl. 13. John Wiley & Sons, pp. 4.9.1-4.9.27.

Inoué, S., O. Shimomura, M. Goda, M. Shribak, and P.T. Tran. 2001. Fluorescence polarization of green fluorescent protein (GFP). Proc. Natl. Acad. Sci. USA 99(7): 4272-4277.

Inoué, S., M. Goda, and R.A. Knudson. 2001. Centrifuge polarizing microscope. II. Sample biological applications. J. Microscopy 201:357-367.

Inoué, S., R.A. Knudson, M. Gouda, K. Suzuki, C. Nagano, N. Okada, H. Takahashi, K. Ichie, M. Lida, and K. Yamanaka. 2001. Centrifuge polarizing microscope. I. Rationale, design, and instrument performance. J. Microscopy 201:341-356.

Inoué, S., and R. Oldenbourg. 1998. Microtubule dynamics in mitotic spindle displayed by polarized light microscopy. Mol. Biol. Cell 9: 1603-1607.