About BIE

BIE is a three-week course that focuses on comparative anatomy, function, and theoretical background, as well as timely subjects in inner ear biology, medical topics and open questions.  These topics will be explored in lecture and laboratory experiments outlined below:

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Comparative Anatomy

  • zebrafish
  • frog
  • chicken
  • mouse

Microscopy

  • SEM
  • Confocal
  • Spinning disk
  • High resolution imaging

Cellular and Developmental Studies

  • Organ cultures
  • Dissociation and isolation
  • Gene delivery
  • Paintfill
  • Optical clearing methods for immunofluorescence

Electrophysiology

  • Intracellular recording from hair cells in cochlear and vestibular epithelium
  • Membrane properties in current and voltage-clamp
  • Mechanotransduction
  • Synaptic signaling

Systems Level Studies

  • Auditory brainstem evoked response (ABR)
  • Distortion product otoacoustic emissions
  • Single unit recording in auditory nerve, brainstem and mid-brain