Student Profile – Yuko Hasegawa
Yuko Hasegawa is a fifth-year graduate student from the MCB Graduate Program. At the MBL, Yuko is advised by Drs. Gary Borisy and Mitch Sogin. She is developing an imaging technique to analyze micron-scale spatial distribution of a synthetic human gut bacterial community using a mouse model. Yuko is particularly interested in simultaneously analyzing multiple target bacterial groups (1) by using a molecular biology technique called fluoresce in situ hybridization (FISH) to fluorescently label specific bacteria of interest and (2) by performing spectral imaging analysis of fluorescent dyes.
Recent Activities:
- Microbial Diversity course, Woods Hole Marine Biological Laboratory, 2009. Characterized deep-sea microbial activities in a whale-fall sediment.
- Session Organizer and Co-Chair for Organized Oral Session. August 2009. “Application of molecular knowledge of microbes to studies of ecological processes: why the integration is so challenging.” The 94th Ecological Society of America Annual Meeting, Albuquerque, New Mexico.
Peer Reviewed Publication:
Chen C. C., A. Motegi, Y. Hasegawa, K. Myung, R. Kolodner, and A. D’Andrea. 2006. Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and Ubiquitination. DNA Repair. 5(12):1475-88.
Hasegawa, Y., J. L. Martin, M. LeGresley, T. Burke, and J. N. Rooney-Varga. 2007. Microbial community diversity in the phycosphere of natural populations of the toxic alga, Alexandrium fundyense. Environmental Microbiology. 9(12):3108-21.
Hasegawa, Y., J. Mark Welch, A. M. Valm, C. Rieken, M. L. Sogin, and G. G. Borisy. 2010. Imaging marine bacteria with unique 16S rRNA V6 sequences by fluorescence in situ hybridization and spectral analysis. Geomicrobiology Journal. 27(3).
Valm, A. M., J. Mark Welch, C.W. Rieken, Y. Hasegawa, R. Oldenbourg, M. L. Sogin, and G. G. Borisy. 2010. Systems level analysis of microbial community organization: Combinatorial labeling and spectral imaging, (CLASI) to image microbial diversity. To be submitted to PNAS.
Other Publication:
Hasegawa, Y., J. E. Hobbie, C. W. Schadt, M. D. Wallenstein, K. A. Smemo, J. Rich, M. N. Weintraub, S. D. Allison, J. W. Edmonds, J. C. von Fischer, J. H. Vineis. 2010. Application of molecular knowledge of microbes to studies of ecological processes: why the integration is so challenging. ESA Bulletin.
