Research at the CDP is divided into two components: Imaging and Electrochemistry/physiology. Each component is composed of separate but collaborative laboratories.
The CDP imaging component focuses on the architectural dynamics of living cells, which encompass the timely and coordinated assembly and disassembly of macromolecular structures essential for the proper functioning and differentiation of cells, the spatial and temporal organization of these structures, and their physiological and genetic control.
Studying the Architectural Dynamics in Living Cells
The CDP imaging component is inspired by advanced optical methods to study the architectural dynamics in living cells. We are developing a new type of polarized light microscope, the LC-PolScope, for the analysis of molecular order directly in living cells with unprecedented sensitivity, resolution and speed.
Based on polarization measurements, we gain insight into submicroscopic structural parameters and non-invasively create contrast where structures are otherwise invisible. We seek interdisciplinary collaborations to conduct research in physical optics for the interpretation of image content and in computational methods for image enhancement and restoration. These physical and engineering projects are stimulated and guided by biological inquiries into the structural basis of cell function.
Physiologically focused research at the CDP, in addition to pursuing studies of biomedical relevance, cell metabolism and transport biophysics, has pioneered the use of electrochemical sensors to define the chemical signatures surrounding living cells and tissue, opening insights to cell function from a distance. This technology development and utilzation is a specialty of the BioCurrents Research Center.
BioCurrents Shared Resource
The BioCurrents Shared Resource (BSR) designs and develops instrumentation for biomedical research. The BSR specializes in the development and utilization of a range of technologies to examine the chemical profiles of the living cell, specifically within the complex and dynamic boundary layer. BRC >>>