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The Biology of the Inner Ear (BIE) course has adapted the intensive and focused approach that typifies MBL courses to provide students with the capacity to address important problems in auditory and vestibular research. Students with backgrounds in biological and physical/computational sciences and scientists new to investigations of the inner ear are particularly encouraged to apply.
Students will learn cutting-edge methods from leaders in inner ear research. Through research seminars, roundtable discussions, lectures, and informal laboratory interactions where students and instructors work side-by-side, this interdisciplinary course will foster the development of the students as investigators, emphasizing opportunities for important discoveries, innovative approaches, and the potential for the translation of discoveries into meaningful improvements in health care.
In the laboratory, students will learn microdissection procedures for harvesting inner ear tissues; methods for culturing inner ear tissues; use of fluorescent and immune probes for light and electron microscope imaging the living and fixed cochlea; modern methods of hair-cell electrophysiology; adenoviral infection, biolistic transfection, and electroporation for introducing genes into hair cells; methods to produce transgenic Xenopus; the use of zebrafish and transgenic mice for investigations of hair cells; the generation of inner-ear stems cells; bioinformatic analysis of gene expression; and other approaches.
State-of-the-art microscopes and other advanced equipment will be available in this course. Students will leave the course with the capacity to investigate fundamental issues in inner ear research.
Distinguished Scholars:
Peter Dallos, Northwestern University
A. James Hudspeth, The Rockefeller University
2007 Faculty
Paul Adler, University of Virginia
Jonathan Ashmore, University College London
James Bartles, Northwestern University
John Brigande, Oregon Health & Science University
David Corey, Harvard Medical School
J. David Dickman, Washington University at St. Louis
Donna Fekete, Purdue University
Andrew Forge, University College London
Paul Fuchs, Johns Hopkins University
Gwenaëlle Géléoc, University of Virginia
Robert Grainger, University of Virginia
Chris Halpin, Harvard Medical School and Massachusetts Eye and Ear Infirmary
Stefan Heller, Stanford University
Stephen Highstein, Washington University at St. Louis
Gay Holstein, Mount Sinai School of Medicine
Frank Jülicher, Max Planck Institute for the Physics of Complex Systems
Bechara Kachar, NIDCD, NIH
Matthew Kelley, NIDCD, NIH
M. Charles Liberman, Harvard Medical School and Massachusetts Eye & Ear Infirmary
Michael Lovett, Washington University at St. Louis
Xiaowei Lu, University of Virginia
Lloyd Minor, Johns Hopkins University
Cynthia Morton, Harvard Medical School
David Raible, University of Washington
Guy Richardson, University of Sussex
Robert Shannon, House Ear Institute
Karen Steel, Wellcome Trust Sanger Institute
Melissa Vollrath, Harvard Medical School
Mark Warchol, Washington University at St. Louis
Jian Zuo, St. Jude's Children's Research Hospital
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