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This course provides
state-of-the-art training in molecular methods for studying fungal
pathogens important in human disease. The course is designed for
advanced graduate students, postdocs, and independent investigators.
Limited to 18 students.
The goal of the course is to instruct students in the application of
molecular methodologies to problems posed by medically important fungi.
The main areas covered by the course include an introduction to
medically important fungi, molecular manipulation and analysis of these
fungi, host-fungal interactions, basic concepts of pathogenesis, and
the application of molecular methods to the analysis of fungal disease.
Training is provided by laboratory exercises, visiting seminar
speakers, and informal panel discussions. Laboratory exercises focus on
Candida, Aspergillus, and Cryptococcus, and
include transformation, gene disruption, gene cloning strategies, in
vivo pathogenicity assays, host response assays, mitotic recombination
and genetic instability, and microscopic analysis of fungi. Invited
seminar speakers will provide introductions to Candida,
Aspergillus, Cryptococcus, Histoplasma, Coccidioides, and Pneumocystis,
as
well
as
more specialized seminars in areas of drug targets,
molecular diagnostic techniques, virulence, genome structure,
evolution, vaccine strategies, and host defenses. Panel discussions
will focus on current research problems and development of new research
techniques and paradigms.
This course is supported with funds provided by
Burroughs
Wellcome Fund
Howard
Hughes Medical Institute
Merck
2010 Faculty and
Lecturers:
Richard Bennett, Brown University
Brendan Cormack, Johns Hopkins University School of Medicine
Marta Feldmesser, Albert Einstein College of Medicine, Yeshiva
University
William Goldman, University of North Carolina
Neil Gow, Aberdeen University
Joseph Heitman, Duke University
James B. Konopka, SUNY Stony Brook
Eleftherios Mylonakis, Massachusetts General Hospital
André Nantel, Biotechnology Research Institute, NRC
Mairi Noverr, LSU Health Sciences
Center
Liise-anne Pirofski, Albert Einstein
College of Medicine, Yeshiva University
Judith C. Rhodes, University of Cincinnati
Donald C. Sheppard, McGill University
Theodore C. White, Seattle Biomedical Research Institute
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