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This course provides state-of-the-art
training in molecular methods for studying fungal pathogens important
in human disease. The course is designed for advanced graduate students,
postdocs, and independent investigators. Limited to 18 students.
The goal of the course is to instruct students in the application
of molecular methodologies to problems posed by medically important
fungi. The main areas covered by the course include an introduction
to medically important fungi, molecular manipulation and analysis
of these fungi, host-fungal interactions, basic concepts of pathogenesis,
and the application of molecular methods to the analysis of fungal
disease.
Training is provided by laboratory exercises, visiting seminar speakers,
and informal panel discussions. Laboratory exercises focus on Candida,
Aspergillus, and Cryptococcus, and include transformation,
gene disruption, gene cloning strategies, in vivo pathogenicity
assays, host response assays, mitotic recombination and genetic
instability, and microscopic analysis of fungi. Invited seminar
speakers will provide introductions to Candida, Aspergillus,
Cryptococcus, Histoplasma, Coccidioides, and Pneumocystis,
as well as more specialized seminars in areas of drug targets, molecular
diagnostic techniques, virulence, genome structure, evolution, vaccine
strategies, and host defenses. Panel discussions will focus on current
research problems and development of new research techniques and
paradigms.
This course is supported with funds provided by
Burroughs Wellcome Fund
Howard Hughes Medical Institute
Merck
2009 Faculty and Lecturers: Dee Carter, University of Sydney Paul Dyer, University of Nottingham Scott G. Filler, Harbor-UCLA Medical Center Neil Gow, University of Aberdeen Joseph Heitman, Duke University Tobias Hohl, Memorial Sloan-Kettering Cancer Center Christina Hull, University of Wisconsin James B. Konopka, SUNY Stony Brook Carol Kumamoto, Tufts University Joachim Morschhäuser, Universität Würzburg Eleftherios Mylonakis, Massachusetts General Hospital Andre Nantel, Biotechnology Research Institute, NRC Judith C. Rhodes, University of Cincinnati Jason Stajich, University of California, Berkeley Theodore C. White, Seattle Biomedical Research Institute
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