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A two-week lecture and laboratory course, experimentally based and problem oriented, intended for graduate students and postdoctoral fellows in the early stages of vision research or planning to enter the field. Students are presented with a comprehensive overview of current research areas and approaches that will help to broaden their understanding of this area. Limited to 24 students.
The goal of this course is to present, in depth, the exciting theoretical and experimental approaches to fundamental research problems in vision so that students can evaluate the potential for active research in this field and broaden and deepen their knowledge of it. The faculty will describe and direct laboratories of ongoing research in the tissues of the eye of invertebrates and vertebrates. Proposed areas of study include: CORNEA: (a) epithelium: development, stem cells, barrier function, immunology, molecular biology of homeobox genes, (b) stroma: wound healing, neovacularization, matrix structure and remodeling, (c) ion channels, cell junctions and transporters and (d) transplantation. ANTERIOR CHAMBER AND LENS: (a) molecular mechanisms of ocular morphogenesis, (b) molecular, cellular, and developmental biology of the lens, with emphasis on the regulation and evolution of gene expression, (c) molecular and cellular basis of transparency and cataract formation, (d) ion channels, cell junctions, and transporters in the function of the lens, and ciliary epithelium, (d) mechanisms of fluid balance and control of intra-ocular pressue and (e) molecular and cellular control of the extracellular matrix. RETINA: (a) photoreceptors: biochemistry, molecular biology, cell biology and physiology of differentiation, signal transduction, and signal transmission; molecular and cellular biology of inherited and age-related retinal degenerations; (b) pigment epithelium: molecular and cellular studies of polarity of membrane proteins; synthesis of interphotoreceptor matrix, growth factors and retinoid carrier proteins; transplantation; (c) central connections: neurophysiology of transmission; contrast and color perception and the physiology of amblyopia; (d) developmental biology and retinal organization; retinal stem cells. ANIMAL MODELS AND GENETICS (a) mouse and other mammalian models for studying vision disorders and probing fundamental mechanisms (b) non-mammalian models, including zebrafish, Xenopus, Drosophila, (c) application of human genetics to understanding disease genes and risk factors (d) new approaches to cell and gene therapy for ocular disease.
The costs of attending the course, including travel, housing and meals at MBL, are fully supported by the National Eye Institute, NIH.
2008 Course Faculty and Lecturers:
Robert Barlow, Institute for Sensory Research, Syracuse University
Ben Barres, Stanford University
David Beebe, Washington University
Eliot Berson, Harvard Medical School
Dean Bok, Jules Stein Eye Institute, UCLA Medical School
Rick Born, Harvard Medical School
Barbara Chapman, University of California, Davis
Jeannie Chen, USC Keck School of Medicine
Nansi Colley, University of Wisconsin
Dusanka Deretic, University of New Mexico
Walter Gehring, Biozentrum, University of Basel
Marion Gordon, Ernest Mario School of Pharmacy, Rutgers University
Alecia Gross, University of Alabama at Birmingham
Jonathan Horton, University of California, San Francisco
Joseph Horwitz, Jules Stein Eye Institute, UCLA Medical School
Abbie Jensen, University of Massachusetts-Amherst
Simon John, Jackson Laboratory Bar Harbor
Richard Lang, Cincinnati Children's Hospital
Jennifer LaVail, University of California, San Francisco
Ellen Liberman, National Eye Institute, NIH
Marsha Moses, Harvard Medical School
Jerry Niederkorn, UT Southwestern Medical Center
Mary Ann Stepp, George Washington University Medical Center
Enrica Strettoi, Italian National Research Council
Stephen Sugrue, University of Florida College of Medicine Jody Summers Rada, University of Oklahoma Health Sciences
Theodore Wensel, Baylor College of Medicine
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