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Over the past 15 years, the zebrafish has emerged as an important model system for the study of vertebrate development and disease. This intensive two-week course for advanced graduate students, postdoctoral fellows, and independent investigators will focus on the development and genetics of zebrafish with special emphasis on the nervous system. The first week of the course will cover early zebrafish development and genetics, while the second week will focus on nervous system development and function. Mornings and afternoons will be devoted mainly to laboratory exercises and the evenings to lectures and discussion. Limited to 22 students.
Lectures and labs in the first week will introduce students to early development of the zebrafish and to methods for manipulating and studying gene function, including mutant screening, mapping and cloning; transgenesis and antisense approaches; mosaic analysis; and in situ methods for detecting gene expression. In the second week, students will be introduced to the nervous system of zebrafish, its organization and development, and methods for the analysis of nervous system mutants including visualizing single neurons in live embryos, labeling and analyzing axon projections, and performing behavioral tests on live animals. Informal “roundtable” discussions held periodically during the course include the design and execution of mutant screens, and zebrafish breeding and husbandry.
Each laboratory exercise will be under the supervision of a senior faculty member who will be assisted by one or two junior faculty members. Senior faculty will give research lectures about their work, in addition to leading discussions on topics covered in the course.
Partial funding for this course is provided by the National Institutes of Health and the Grass Foundation.
2007 Course Faculty & Lecturers:
R. Charline (Walker) Durchanek, University of Oregon
Jon Clarke, UCL
Andres Collazo, House Ear Institute
John Dowling, Harvard University
James Fadool, Florida State University
Joseph Fetcho, Cornell University
Michael Granato, University of Pennsylvania, SOM
Corinne Houart, King's College London
Charles Kimmel, University of Oregon
Stephan Neuhauuss, University of Zurich
Randall Peterson, MGH
David Raible, University of Washington
William Talbot, Stanford University
Stephen Wilson, University College London
Deborah Yelon, Skirball Institute, NYU School of Medicine
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