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An intensive six-week laboratory and lecture course for advanced graduate students, postdoctoral fellows, and more senior researchers who seek a broad and balanced view of the modern issues of developmental biology. Limited to 24 students.
The integrated lectures and laboratories provide a comprehensive coverage of the paradigms, problems, and technologies of modern developmental biology, cast within a framework of metazoan evolution. Students are exposed to a wide variety of embryonic systems, including intensively studied genetic model systems ( e.g. C. elegans , Drosophila , zebrafish mouse) and others with well-established experimental attributes ( e.g. chick, sea urchins, frogs, ascidians). In addition, students will be introduced to a wide range of emerging systems, including locally available marine organisms, that help fill in the evolutionary history of animal diversity ( e.g. cnidarians, nemerteans, planaria, crustaceans, mollusks, and annelids) and that are becoming established as experimental systems in their own right. This broad coverage of metazoan phylogeny allows for the analyses of the developmental strategies that drive evolutionary change. Analytical and experimental techniques used to explore invertebrate and vertebrate development include embryological manipulation (e.g. cell ablation, tissue grafting), molecular genetic ( e.g. RNAi, electroporation) and cell biology approaches ( e.g. analysis of cell lineage and migratory behaviour), and microscopic and imaging technologies (e.g. confocal and 3-D time lapse), using state-of-the-art instrumentation and methodology. Conceptual topics include cell specification and differentiation, pattern formation, embryonic axis formation, morphogenesis, intercellular signaling, transcriptional regulation, organogenesis, and modern comparative embryology.
This course is supported in part by a grant from the National Institute of Child Health and Human Development, NIH. Support is also provided by the Company of Biologists Ltd., and the Society for Developmental Biology.
2007 Faculty and Lecturers:
Sharon Amacher, University of California, Berkeley
Clare Baker, University of Cambridge
Richard Behringer, MD Anderson Cancer Center
Marianne Bronner-Fraser, California Institute of Technology
C. Titus Brown, California Institute of Technology
Andres Collazo, House Ear Institute
Cassandra Extavour, University of Cambridge
Marie-Anne Felix, Institut Jacques Monod
Scott Fraser, California Institute of Technology
John Gerhart, University of California, Berkeley
Richard Harland, UC Berkeley
Jonathan Henry, Univerisity of Illinois
Raymond Keller, University of Virginia
Nicole King, UC Berkeley
Catherine Krull, University of MichiganDavid Lambert, University of Rochester
Michael Levin, Forsyth Institute/Harvard University
Amy Maddox, University of California at San Diego
Mark Martindale, Univ. Hawaii
David McClay, Duke University
Denise Montell, Johns Hopkins School of Medicine
Paola Oliveri, Caltech
Kimberly Perry, University of Illinois
Olivier Pourquie, HHMI/Stowers Institute for Medical Resea
Daniel Rokhsar, UC Berkeley
Joel Rothman, UC Santa Barbara
Alejandro Sanchez Alvarado, HHMI, University of Utah
Joshua Sanes, Harvard
Elaine Seaver, University of Hawaii
Lori Sussel, University of Colorado Health Sciences
Maximilian Telford, University College London
Paul Trainor, Stowers Institute
Eric Wieschaus, Princeton University
Deborah Yelon, Skirball Institute, NYU School of Medici
Robert Zeller, San Diego State University
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