Course Date: June 2 – July 31, 2016

Deadline: February 1, 2016 | Apply here

2015 Syllabus & Lecture Schedule

Directors: Graeme Davis, University of California, San Francisco; Andres Maricq, The University of Utah; and Timothy A. Ryan, Weill Medical College of Cornell University

An intensive and comprehensive laboratory-oriented course in cellular and molecular neurobiology intended for predoctoral students, postdoctoral or clinical researchers, and young investigators beginning independent research careers. Limited to 14 students.

A hallmark of this course is the extensive lab work done in close collaboration with expert faculty. The course is divided into three sections: Electrophysiology, Imaging, and Molecular Neurobiology. These are taught by separate groups of faculty, usually six in each section, and with many guest lecturers. Each section begins with specific training in core laboratory techniques; students then undertake one- to two-week directed or independent projects using the methods they have learned. Didactic lectures are combined with laboratory experience in order to establish a strong conceptual foundation for each section. A typical day has 3 hours of lecture and 10 hours of lab.

Electrophysiological methods focus on patch-clamp and sharp electrode recordings, performed on neurons in a variety of preparations, including tissue culture, brain slices, isolated squid synapses, rat cochlea, or whole fish. Optical methods include calcium imaging, confocal and 2-photon microscopy, videomicroscopy, and electron microscopy. Molecular techniques emphasize the use of forward and reverse genetics in diverse systems such as Drosophila, C. elegans, zebrafish, chick embryos, and primary cells in culture. The impact of genetic manipulations are assayed by real time PCR, laser microdissection, single cell PCR, in situ hybridization, and a variety of immunotechniques in addition to incorporating electrophysiological and imaging techniques.

The goal of the course is to emphasize the strengths of a multidisciplinary approach for studying the function of the nervous system at the cellular and molecular levels.

This course is supported with funds provided by:
National Institute of Mental Health, NIH
Howard Hughes Medical Institute
The Grass Foundation
International Brain Research Organization
Genentech, Inc.

2015 Course Faculty & Lecturers:

Abrahamsson, Sara, The Rockefeller University
Aizenman, Carlos, Brown University
Alavian, Kambiz, Imperial College London
Angueyra, Juan, National Institutes of Health
Araneda, Ricardo, University of Maryland
Bamji, Shernaz, University of British Columbia
Bautista, Diana, University of California Berkeley
Bean, Bruce, Harvard Medical School
Buchanan, Joann, Allen Institute for Brain Science
Diaz, Elva, University of California Davis
Eaton, Benjamin, The University of Texas Health Science Center
Feller, Marla, University of California Berkeley
Gina, Poe, University of Michigan
Hammarlund, Marc, Yale University
Hess, Sam, University of Maine
Higley, Michael, Yale University
Johnston, Daniel, University of Texas at Austin
Jorgensen, Erik, University of Utah
Kanold, Patrick, University of Maryland
Kim, Charlie, University of California San Francisco
Kirkwood, Alfredo, Johns Hopkins University
Lichtman, Jeff, Harvard University
Looger, Loren, Howard Hughes Medical Institute
Lumpkin, Ellen, Columbia University
Mackinnon, Roderick, The Rockefeller University
Marder, Eve, Brandeis University
Misgeld, Thomas, Technical University Munich
Mueller, Martin, University of Zurich
Nishi, Rae, University of Vermont
Nitabach, Michael, Yale University
Parrish, Jay, University of Washington
Peterka, Darcy, Columbia University
Reese, Thomas, National Institutes for Health/Division of Intramural Research
Ruta, Vanessa, The Rockefeller University
Sack, Jon, University of California Davis
Sagasti, Alvaro, University of California Los Angeles
Sanders, Stephan, University of California San Francisco
Tomita, Susumu, Yale University
Von Zastrow, Mark, University of California San Francisco
Yasuda, Ryohei, Max Planck Florida Institute
Zuo, Yi, University of California Santa Cruz