October 5, 2015



Course Date: June 2 – July 31, 2016

Deadline: February 1, 2016 | 2016 Application Coming Soon

2015 Syllabus & Lecture Schedule

Directors: Graeme Davis, University of California, San Francisco; and Timothy A. Ryan, Weill Medical College of Cornell University

An intensive and comprehensive laboratory-oriented course in cellular and molecular neurobiology intended for predoctoral students, postdoctoral or clinical researchers, and young investigators beginning independent research careers. Limited to 14 students.

A hallmark of this course is the extensive lab work done in close collaboration with expert faculty. The course is divided into three sections: Electrophysiology, Imaging, and Molecular Neurobiology. These are taught by separate groups of faculty, usually six in each section, and with many guest lecturers. Each section begins with specific training in core laboratory techniques; students then undertake one- to two-week directed or independent projects using the methods they have learned. Didactic lectures are combined with laboratory experience in order to establish a strong conceptual foundation for each section. A typical day has 3 hours of lecture and 10 hours of lab.

Electrophysiological methods focus on patch-clamp and sharp electrode recordings, performed on neurons in a variety of preparations, including tissue culture, brain slices, isolated squid synapses, rat cochlea, or whole fish. Optical methods include calcium imaging, confocal and 2-photon microscopy, videomicroscopy, and electron microscopy. Molecular techniques emphasize the use of forward and reverse genetics in diverse systems such as Drosophila, C. elegans, zebrafish, chick embryos, and primary cells in culture. The impact of genetic manipulations are assayed by real time PCR, laser microdissection, single cell PCR, in situ hybridization, and a variety of immunotechniques in addition to incorporating electrophysiological and imaging techniques.

The goal of the course is to emphasize the strengths of a multidisciplinary approach for studying the function of the nervous system at the cellular and molecular levels.

This course is supported with funds provided by:
National Institute of Mental Health, NIH
Howard Hughes Medical Institute
The Grass Foundation
International Brain Research Organization
Genentech, Inc.

2014 Course Faculty & Lecturers:

Aizenman, Carlos, Brown University
Araneda, Ricardo, University of Maryland
Arbeitman, Michelle, Florida State University
Bautista, Diana, University of California Berkeley
Bezanilla, Francisco, University of Chicago
Buchanan, Joann, Stanford University
Carlson, John, Yale University
Chevaleyre, Vivien, CNRS
Commons, Kathryn, Children’s Hospital/Harvard Med
Diaz, Elva, University of California Davis
Dombeck, Daniel, Northwestern University
Eaton, Benjamin, University of Texas Health Science Center San Antonia
Feng, Guoping, Massachusetts Institute of Technology
Hammarlund, Marc, Yale University
Hess, Sam, University of Maine
Hoppa, Michael, Weill Cornell Medical College
Kaplan, Joshua, Massachusetts General Hospital
Khodakhah, Kamran, Albert Einstein College of Medicine
Kravitz, Edward, Harvard Medical School
Lichtman, Jeff, Harvard University
Llano, Isabel, CNRS
Mackinnon, Roderick, The Rockefeller University/HHMI
Magee, Jeffrey, Howard Hughes Medical Institute
Martin, Kelsey, University of California Los Angeles
Marty, Alain, CNRS
Micheva, Kristina, Stanford University
Nelson, Sacha, Brandeis University
Oertner, Thomas, Center for Molecular Neurobiology Hamburg
Parrish, Jay, University of Washington
Peterka, Darcy, Columbia University/HHMI
Pratt, Kara, University of Wyoming
Raman, Indira, Northwestern University
Reese, Tom, NINDS/NIH
Sack, Jon, University of California Davis
Sagasti, Alvaro, University of California Los Angeles
Shen, Kang, Stanford University
Smith, Stephen, Stanford University School of Medicine
Trussell, Larry, Oregon Health & Science University
Vokoun, Corinne, University of Wisconsin
Von Zastrow, Mark, University of California San Francisco
Yasuda, Ryohei, Max Planck Florida Institute for Neuroscience
Zuo, Yi, University of California Santa Cruz