Date(s) - 03/29/2013
Cellular Dynamics Seminar – “Development of Therapeutics to Suppress Growth of Tumors Found in Neurofibromatosis (NF)”
Shanta Messerli, CDP Associate Research Scientist
Neurofibromatosis, also known as NF, is a genetically inherited disorder of the nervous system which mainly affects the development of nerve (neural) cell tissues, causing tumors to develop on nerves, and may cause other abnormalities. The tumors may be harmless, or may compress nerves or other tissues, causing serious damage and or pain. In some cases of NF the tumors may become cancerous. NF includes three different genetic conditions, neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and multiple schwannomatosis. NF research is a critical area for future scientific investigations, and a further understanding of the genetic basis of this disease may provide insight into how cancer develops and new approaches to cancer treatments. We have been exploring different therapeutic avenues for treatment of NF, including gene therapy and natural products, as well as mechanisms of actions of these therapeutics.