The Jean & Katsuma Dan Lectureship in Embryology/Physiology: “Stem cells: breakthroughs, battles, myths, and medicines”

Date(s) - 07/11/2012
4:00 pm - 5:00 pm
Lillie Auditorium

The Jean & Katsuma Dan Lectureship in Embryology/Physiology
“Stem cells: breakthroughs, battles, myths, and medicines”
George Q. Daley, Children’s Hospital Boston, Harvard Medical School, HHMI
Lillie Auditorium, 4:00 PM

George DaleyGeorge Q. Daley, M.D., Ph.D. is the Samuel E. Lux IV Professor of Hematology/Oncology and the Director of the Stem Cell Transplantation Program at Children’s Hospital Boston, Professor of Biological Chemistry and Molecular Pharmacology and Pediatrics at Harvard Medical School, and an investigator of the Howard Hughes Medical Institute. He is past-President of the International Society for Stem Cell Research (‘07-‘08), and formerly Chief Resident in Medicine at MGH (‘94-‘95). Daley’s research contributions include the derivation of patient-specific induced pluripotent stem cells for over a dozen human diseases, demonstration of combined gene and cell therapy via customized stem cells, and creation of a murine model of human chronic myeloid leukemia that validated BCR/ABL as a drug target. Dr. Daley received his bachelor’s degree magna cum laude from Harvard University (1982), a Ph.D. in biology from MIT (1989), and the M.D. from Harvard Medical School summa cum laude (1991). Dr. Daley has received the NIH Director’s Pioneer Award, the Judson Daland Prize from the American Philosophical Society, the E. Mead Johnson Award from the American Pediatric Society, and the E. Donnall Thomas Prize from the American Society for Hematology. He has been elected a member of the Institute of Medicine of the National Academies, American Society for Clinical Investigation, American Association of Physicians, and American Pediatric Societies, and a fellow of the American Academy of Arts and Sciences and American Association for the Advancement of Science. Dr. Daley took the Physiology course at MBL in the summer of 1982.


Jean Clark and Katsuma Dan met when they were graduate students of the American physiologist, L.V. Heilbrunn. They studied with him at the University of Pennsylvania and spent their summers at the MBL. Katsuma Dan received his Ph.D. in 1934; Jean Clark received hers in 1936 after which they married and settled in Nagai, a five-mile bike ride to their laboratory in Misaki. They came from vastly different backgrounds: He was the son of a wealthy Japanese baron and she was from Presbyterian Yankee stock, but they shared a love for science, Woods Hole, and the MBL.

Katsuma Dan was one of Japan’s most influential and original biologists, a skillful administrator, and a scientific statesman. He was credited with original studies of marine organisms, their cell division, fertilization, early development, cell differentiation, and lunar-influenced spawning cycles. Katsuma Dan died in 1996 in Osaka, Japan, at the age of 91.

Jean Dan was the progenitor of an international effort to understand the interaction between the sperm and the egg; she discovered the acrosomal reaction that unites sperm to egg cell membrane. Her superb translations of Japanese biological works into English have been instrumental in the export of Japanese discovery to the West. Jean died in 1978, and her ashes were brought back from Japan and scattered on the water near Nobska Point.

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