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Questions/comments:
cdematos@mbl.edu
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2009 KMCB Meeting: Announcements & Job Postings Online
| Posting announcements:
Announcements may be posted by logging in to the MPM site
using the e-mail address and password that were chosen when first registering
for the 2009 meeting. If you would like to post an announcement on this page but
did not apply to attend the meeting please
e-mail us.
List of announcements (in the order posted):
Job opening posted on Thu Mar 19 11:03:24 2009 by Robert Campbell
Postdoctoral Position at MBL for Trypanosome Drug Discovery Project
A postdoctoral position in trypanosome microbiology and drug discovery is available in the lab of Bob Campbell at the Marine Biological Lab, Woods Hole. We seek a Postdoctoral Scientist to contribute to an NIH-supported project to discover enzyme inhibitors suitable as drug leads for treatment of African trypanosomiasis (sleeping sickness). The T. brucei genome contains numerous homologs of human proteins that have been successfully exploited as drug targets. This collaborative project seeks to exploit these similarities to reposition established chemistry expertise from human targets to trypanosomes. The current focus is on cyclic nucleotide phsophodiesterases, and the goal is to identify compounds with in vitro and in vivo pharmacology that justify entry into development. The Postdoctoral Scientist will be part of a collaborative project team combining molecular, cell, and computational biology at MBL with medicinal chemistry and in vivo studies at other institutes. The Postdoctoral Scientist will be expected to provide strong leadership in all aspects of the parasite biology needed for the project, including RNAi and drug candidate testing in cultured trypanosomes, assessment of biochemical and morphological phenotypes associated with compound action, and coordination of compound testing with the PIs and the WHO TDR testing network. The postdoc will also be expected to learn and utilize molecular modeling and docking tools to contribute to analysis and interpretation of structure-activity data from candidate compounds.
For more information, please see:
http://jbpc.mbl.edu/labs-campbell.html
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-08-005.html
The successful applicant must hold a Ph.D. in molecular parasitology or a related field. Essential skills include culture, transfection, cloning, biochemical analysis, and microscopic analysis of trypanosomes. Excellence in regular, proactive communication and problem solving as part of a team is also essential; as are strong record-keeping, a great work ethic, and initiative. Additional skills in molecular biology, protein purification and biochemical characterization, and bioinformatics are a plus.
Job opening posted on Tue Mar 31 17:58:09 2009 by Roberto Docampo
Postdoctoral positions at the University of Georgia
Postdoctoral positions are available in the laboratory of Roberto Docampo (rdocampo@uga.edu) at the Center for Tropical and Emerging Global Diseases, University of Georgia, to study trafficking of proteins to the acidocalcisomes of Trypanosoma brucei and to understand the roles of polyphosphate accumulated in acidocalcisomes of this parasite. The acidocalcisome is a lysosome-related organelle involved in the regulation of calcium, pH, and osmotic homeostasis in parasitic protists and is conserved from bacteria to man. Polyphosphate is present in every cell in nature and plays essential roles in bacterial virulence, and blood coagulation. Many other roles are waiting to be discovered and T. brucei is an excellent model to study its functions. Preference will be given to applicants with strong background in molecular biology and/or cell biology.
For more information, please see: http://docampo_moreno.ctegd.uga.edu/
Job opening posted on Wed Apr 22 11:46:04 2009 by Ziyin Li
Postdoctoral positions at UT Health Science Center at Houston
Postdoctoral positions are available at the University of Texas Health Science Center at Houston to study the molecular mechanisms of mitosis and cytokinesis in Trypanosoma brucei. We have recently identified a novel chromosomal passenger complex (CPC) that promotes chromosome segregation and cytokinesis in trypanosomes. The CPC displays a dynamic trans-localization from the chromosome kinetochores to the spindle midzone and then crosses the nuclear envelope and travels to the anterior end of the daughter flagellum to initiate cytokinesis. The complex finally spearheads along the cleavage furrow toward the posterior of the cell to separate the cell into two. This unique mode of cell division mediated by the CPC has never been observed in any other organisms, suggesting an unusual mechanism of cytokinesis in trypanosomes. Future work is directed to identify the downstream factors of the chromosomal passenger complex and to characterize their roles in regulating cytokinesis initiation and completion.
Self-motivated and career-oriented recent Ph.D. graduates with strong background in biochemistry, cell biology and molecular biology are encouraged to apply. For more information, please email Dr. Ziyin Li (ziyin.li@ucsf.edu).
Job opening posted on Thu Apr 23 18:52:40 2009 by Michael Boshart
Postdoc position for signal transduction in T. brucei. at University of Munich
Postdoctoral position to study signaling mechanisms and differentiation of Trypanosoam brucei in the group of Michael Boshart. You will study candidate signaling proteins involved in differentiation, that have been identified by RNAi screening of the kinome and by phosphoproteomics. The Biocenter at the Martinsried campus of the University of Munich provides a stimulating scientific environment and excellent facilities. A background in molecular biology, cell biology or biochemistry is required. For more information contact me at this meeting or mailto: boshart@lmu.de
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