Mouse Hippocampus Module

This cycle will use behavioral and electrophysiological approaches to explore hippocampal function in mice. Thanks to a generous donation of mice by The Jackson Laboratory, this year students will also have the opportunity to study hippocampal function and cognition in a mouse model of Huntington’s Disease (HD).

Students will learn how to assess hippocampus-dependent cognitive functions in these animals and their wild type controls using behavioural tasks. Electrophysiological recordings of single unit activity and local field potentials using tetrode arrays in awake behaving mice will be used to explore the properties of hippocampal place cells and hippocampal network activity in normal and transgenic animals. Electrophysiological recordings of evoked synaptic responses and neuronal excitability in hippocampal slices will be used to explore the properties synaptic circuits and spike activity in normal and transgenic animals.

The first week of the cycle will comprise exercises that teach the basic principles and techniques of behavioral testing, in vivo single unit and local field potential recording in awake behaving mice, and ex vivo extracellular and patch clamp recording in hippocampal slices. During, the second week, students will carry out experiments that they have designed to address a specific question about the relationship between hippocampal neural activity and/or synaptic function and cognition function, and/or how these may be altered in HD model mice.

Mouse Hippocampus Faculty and Teaching Assistants

mvdm_smallMatt van der Meer
Dartmouth

I am interested in how neural activity in the brain relates to behavior, with particular focus on the interplay between learning, memory, and decision-making. In my lab, we use (a) experimental tools for the simultaneous and long-term recording of large numbers of neurons across multiple brain areas during specific behaviors, and (b) data analysis and computational modeling frameworks that draw on concepts and tools from statistics, machine learning, and related fields. Our work so far has focused primarily on the rodent hippocampus and ventral striatum, which display a rich set of neural activity patterns indicative of the prediction and evaluation of possible spatial trajectories for navigation. Matt was an NS&B student in 2005. He joined the Hippocampus faculty in 2014.

 

AndreFenton1André Fenton
New York University

André Fenton, is a neuroscientist, biomedical engineer and entrepreneur working on three related problems: how brains store information in memory; how brains coordinate knowledge to selectively activate relevant information and suppress irrelevant information; and how to record electrical activity from brain cells in freely-moving subjects. André and colleagues identified PKMzeta as the first molecule demonstrated to be crucial for the persistence of memories, lasting at least a month. Recordings of electrical brain activity in André’s lab are elucidating the physiology of cognitive dysfunction that is a core feature in mental illness. We recently discovered that preemptive cognitive training during adolescence changes the brain sufficiently to prevent the adult brain dysfunction and cognitive impairments that arises from brain damage during early life in a schizophrenia-related animal model. André founded Bio-Signal Group Corp., which is developing an FDA-approved, inexpensive, miniature wireless EEG system for functional brain monitoring of patients in emergency medicine and other clinical scenarios where EEG is needed but impractical. André Fenton has been a Course Co-Director and Hippocampus faculty member since 2013.

 
alyssa-carey

Alyssa Carey
Dartmouth

Alyssa completed her graduate studies at the University of Waterloo in Canada, and spent some time as a research assistant at Dartmouth College in the USA. During her time as a neuroscientist, she recorded from hippocampal place cells while rats were performing a motivational shift task. She is now working in the medical devices industry. Alyssa joined the Hippocampus team in 2017.