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This laboratory pursues studies of the molecular mechanism and control of mitosis, cell division, and cell morphogenesis, with emphasis on biophysical studies made directly on single living cells, especially developing eggs in marine invertebrates. Development of biophysical instrumentation and methodology, such as the centrifuge polarizing microscope, high-extinction polarization optical and video microscopy, digital image processing techniques including dynamic stereoscopic imaging, and exploration of their underlying theory are an integral part of the laboratory's effort.
Distinguished Scientist Shinya Inoué
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Education:
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| 1951 |
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Ph.D. Biology, Princeton University |
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| 1950 |
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M.A. Biology, Princeton University |
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| 1944 |
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Rigakushi Zoology, Tokyo University |
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Honors:
International Prize for Biology from the Japan Society for the Promotion of Science, December 2003
National Academy of Sciences, Elected, April 1993
Selected Publications:
Hoffman, J.F., and S. Inoué. 2006. Directly obsereved reversible shape changes and hemoglobin stratification during centrifugation of human and Amphiuma red blood cells. Prov. Natl. Acad. Sci. USA 103(8): 2971-2976.
Shribak, M., and S. Inoué. 2006. Orientation-independent differentiation interference contrast microscopy. Applied Optics 45(3): 460-469.
Inoué, S. 2003. Exploring living cells and molecular dynamics with polarized light microscopy. In P. Török and K. Kao, eds., Optical Imaging and Microscopy, Vol. 87. Springer-Verlag, Berlin Heidelberg, pp. 3-20.
Inoué, S. 2002. Polarization microscopy. In J. Lippincott-Schwartz, ed., Current Protocols in Cell Biology, Suppl. 13. John Wiley & Sons, pp. 4.9.1-4.9.27.
Inoué, S., and T. Inoué. 2002. Direct-view high-speed confocal scanner—the CSU-10. In B. Matsumoto, ed., Cell Biological Applications of Confocal Microscopy, 2nd Edition. Academic Press, pp. 87-123.
Inoué, S., O. Shimomura, M. Goda, M. Shribak, and P.T. Tran. 2001. Fluorescence polarization of green fluorescent protein (GFP). Proc. Natl. Acad. Sci. USA 99(7): 4272-4277.
Inoué, S., M. Goda, and R.A. Knudson. 2001. Centrifuge polarizing microscope. II. Sample biological applications. J. Microscopy 201: 357-367.
Inoué, S., R.A. Knudson, M. Gouda, K. Suzuki, C. Nagano, N. Okada, H. Takahashi, K. Ichie, M. Lida, and K. Yamanaka. 2001. Centrifuge polarizing microscope. I. Rationale, design, and instrument performance. J. Microscopy 201: 341-356.
Inoué, S., and R. Oldenbourg. 1998. Microtubule dynamics in mitotic spindle displayed by polarized light microscopy. Mol. Biol. Cell 9: 1603-1607.
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