November 27, 2014

UChicago-MBL-Argonne Workshops on Cell Dynamics and Advanced Imaging

Xenopus kidney cells by MBL scientists Amitabh Verma, Michael Shribak, and Tomomi Tani.

Xenopus kidney cells by MBL scientists Amitabh Verma, Michael Shribak, and Tomomi Tani.

MBL Scientists are invited to participate in a series of workshops on Cell Dynamics and Advanced Imaging. The MBL-UChicago affiliation has provided the impetus for new efforts to integrate and further develop imaging research throughout the University of Chicago. Although there is significant imaging related research on the University of Chicago, Argonne and MBL campuses, it has not been well coordinated to date.

We propose to convene a series of workshops to start promoting interactions among the different parties. Initially, we hope to gain insights into the expertise available on campus, stimulate new collaborations, and explore future common activities. The workshops will be held on several Saturdays during the rest of the academic calendar. Each workshop will feature talks that highlight active projects in which imaging plays a major role.

These workshops are designed to facilitate communication between cell biologists, cellular neurobiologists, developmental biologists and structural biologists using imaging. We also strongly encourage participation by groups developing and engineering new electron and light microscopy techniques, groups developing and engineering new probes for imaging and computational scientists working on imaging. Together, we aim to identify the new areas and technologies needed to move Cell Dynamics and Advanced Imaging forward at the three different campuses.

Each workshop will run from ~1-5 pm and will feature ~8 talks that represent the interest groups mentioned above, including colleagues from Argonne and MBL. The speakers will be selected so that each workshop features a diverse set of talks designed for a diverse audience. We are guaranteed to learn a lot of new science and better appreciate the imaging capabilities we have on our three campuses.

To indicate your interest in attending these workshops and or presenting at the workshops, please fill out this short form (http://goo.gl/forms/A7n9ccimgH). There will be no registration fee for the workshops.

Updating Cowdry at the MBL: A Workshop on the Past, Present, and Future of Cell Biology

Hull Court at the University of Chicago was built by Charles O. Whitman, first director of the MBL.

Hull Court at the University of Chicago was built by Charles O. Whitman, first director of the MBL.

In 1924 Edmund Cowdry published his General Cytology as a collaborative effort of leading biologists who worked together each summer at the MBL. These included such notables as E.B. Wilson, Thomas Hunt Morgan, and Frank Lillie. Cowdry noted that General Cytology was intended as a state of the art textbook and reference “concerning the cell fundamental.” To some extent, the volume represents a watershed in the transformation of cytology into cell biology.

On October 23rd and 24th, 2014 the University of Chicago and Arizona State University will hold a workshop entitled “Updating Cowdry at the MBL” at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts. The workshop asks “How do we define cell biology in the 21st century?” To answer this question, more than twenty leading cell biologists, historians of biology, and philosophers of biology will convene for presentations and discussions.

For more information or to register for this workshop, please click here.

 

Donation from Millicent and Eugene Bell Foundation Supports New UChicago Professorship in Tissue Engineering with Appointment in MBL’s Bell Center

By Jeremy Manier, University of Chicago

The University of Chicago is creating a new professorship in tissue engineering to promote innovative work at the University’s Institute for Molecular Engineering and the Marine Biological Laboratory, supported by a $3.5 million donation from the Millicent and Eugene Bell Foundation.

The starlet sea anemone (Nematostella) is an emerging model organism for the study of regeneration. Credit: Adam Reitzel, courtesy of John R. Finnerty

The starlet sea anemone (Nematostella) is an emerging model organism for the study of regeneration. Credit: Adam Reitzel, courtesy of John R. Finnerty

The Eugene Bell Professorship in Tissue Engineering will reside within the Institute for Molecular Engineering. That endowed chair holder also will direct a research project at the MBL’s Eugene Bell Center for Regenerative Biology and Tissue Engineering, and will have an appointment at the Bell Center. The MBL and UChicago formed an affiliation in 2013 to advance biological research and education at both institutions.

Tissue engineering and regenerative biology have the potential to produce breakthroughs in healing damaged body parts or even growing new organs. They are inherently multidisciplinary fields, drawing from new technology in materials science and fabrication as well as basic research in fields such as genetics and cell biology.

“The emerging collaborations between scientists at the University and the MBL are well suited to address the scientific challenges of tissue engineering,” said President Robert J. Zimmer. “Many innovations in medical treatments depend on robust links of basic research and new technology. We are grateful for the generous support of the Millicent and Eugene Bell Foundation, which will allow our scholars to do pioneering work in the rapidly changing field of tissue engineering.”

The new professorship will foster scholarship on tissue engineering at the MBL and the Institute for Molecular Engineering, where scientists are focused on exploring innovative technology at the molecular scale, with the potential for societal impact in areas including health care, computing, energy and the environment.

“We have a very unusual chance with our colleagues at the MBL to bring together different scientific perspectives and specialties in search of breakthrough discoveries that could have profound impacts for patients,” said Matt Tirrell, the founding Pritzker Director of the Institute for Molecular Engineering.

For more than a century, scientists at the MBL in Woods Hole, Mass. have studied how certain marine species are able to regenerate damaged tissue. The MBL’s Bell Center includes a national resource for research on the frog called Xenopus, which has unique regenerative abilities and is a major animal model for biomedical research.

“This extraordinary gift from the Millicent and Eugene Bell Foundation continues the Bell family’s generous support of the Marine Biological Laboratory by providing a transformative research opportunity in our affiliation with the University of Chicago,” said MBL President and Director Joan Ruderman.

Millicent Bell, a trustee of the Marine Biological Laboratory since 2009, made the gift through the Bell Foundation in memory of her late husband, Dr. Eugene Bell, a longtime member of the MBL scientific community. While a professor at MIT from 1956 to 1986, Eugene Bell founded the field of tissue engineering through efforts to generate replacement tissue for treating severe burns and other injuries. After retiring from MIT, Eugene Bell founded two companies: Organogenesis Inc., to produce replacement skin, and TEI Biosciences, which used expertise in regenerative medicine to develop new biologic products for various soft tissue repair applications.

“Gene would have been delighted to see how beautifully his hopes for a grand future for tissue engineering are going forward, and I am overjoyed to be able to continue to help in the effort,” Millicent Bell said. “I am looking forward to the prospect of advanced research and of its medical application that will result—and am extremely pleased to see Gene’s humane dreams realized.”

Millicent Bell is a retired professor of English at Boston University and the author of numerous books, including Edith Wharton and Henry James: The Story of their Friendship and Marquand: An American Life. She is the recipient of many honors, including a Howard Foundation fellowship, the Shell Award, a Guggenheim fellowship and the Winship Prize for biography. Her longtime support of the MBL includes gifts totaling $8 million to help establish the Bell Center in 2010.

Second Scientific Retreat Moves MBL, University of Chicago Toward “A New Era in Discovery”

Attendees gather on the steps of the MBL’s Lillie Building during the MBL-University of Chicago Second Scientific Retreat, May 3, 2014. Photo by Tom Kleindinst

By Diana Kenney

Keeping up the momentum after their first retreat in Chicago in February, faculty and scientists from the Marine Biological Laboratory (MBL)’s year-round and visiting scientist communities, the University of Chicago, and Argonne National Laboratory convened for a second retreat at the MBL in May. The MBL, located in Woods Hole, Mass., and the University of Chicago affiliated last year.

-View the Retreat Program-

-View the Retreat Slideshow-

Through wide-ranging, lively discussions about the big research questions the affiliation is uniquely positioned to address, the 190 retreat participants emerged with several key scientific themes for the University and the MBL to explore.

“There are two parts to an affiliation like ours: vision and strategy,” said Karl Matlin, professor in UChicago’s Surgery Department and co-chairman of the retreat committee, which was comprised of University and MBL scientists. “In designing this retreat, our goal was to put both the vision and the strategy in your hands,” Matlin said to the gathering in MBL’s Lillie Auditorium.

“This was scientists getting together, discussing what they want the MBL-UChicago affiliation to become,” said Joel Smith, MBL’s associate director of education and co-chair of the retreat. “There was a palpable sense the affiliation offers unique opportunities for world-leading science; goals the individual institutions could not achieve on their own.”

Shaping a Vision

The retreat kicked off with the attendees discussing, in randomly assigned breakout groups, “Which important scientific questions are the affiliates best positioned to address at a world-class level?” These stimulating, cross-disciplinary conversations generated a list of 35 compelling scientific questions, which the attendees evaluated later in the day. It eventually became apparent that the scientific questions could sort under a few broadly defined categories: Imaging; Computational Biology; Organisms; and Seed/Collaborations, the latter being a cross-cutting request for more opportunities for MBL and UChicago scientists to interact through mechanisms such as seed grants for early research.

“This was an inclusive process in which everyone present had a voice, including a large number of MBL summer investigators,” said neurobiologist Steve Zottoli, an MBL adjunct senior scientist from Williams College and a member of the retreat committee. “Of the four emerging categories, everybody had a stake in one of them, or part of one. It was remarkable how the participants arrived at what they thought were the strengths of the MBL, the strengths UChicago brings, and what could be the best first steps.”

The “Imaging” category, for example, embraces imaging life across multiple scales, from atomic to ecosystems, and pulls in scientists from many disciplines, including biologists, physicists, computer scientists, and environmental scientists. The “Computational Biology” category is also inclusive, with research ideas ranging from gene regulatory networks in developmental and cancer biology, to neural networks, to microbiomes in human and animal health, to global biogeochemistry networks. While the “Organism” category focuses on marine animals, it includes other model organisms, such as Xenopus and zebrafish, as well as marine microbial communities.

“We are moving our mindset from a two-institution view to a more unified one, which is the most important thing,” said Jonathan Gitlin, MBL’s Deputy Director for Research and Programs. “It’s the intellectual capital that really drives this affiliation. We have the opportunity to ask, ‘What incredible scientific questions can the MBL and UChicago get traction on, that nobody else can?’ Answering that takes thinking like one institution.”

“It’s important to realize that this retreat was a very positive starting point; not a fait accompli,” Zottoli said. “We will continue discussing [the scientific goals of the affiliation] all summer long in the MBL’s Whitman Center for Visiting Research, where I am on the planning committee.” To further engage MBL course faculty and visiting researchers, another retreat is planned for summer 2015 at the MBL.


Second MBL-University of Chicago Retreat Slideshow
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From Vision to Strategy

On the second morning of the retreat, breakout groups met to identify the critical first steps needed to move forward in these emerging scientific areas. “This is the strategy part of the affiliation,” Matlin said.

Those strategic recommendations will be considered by the MBL and University of Chicago faculty advisory committees, which are responsible for fostering and developing the affiliation through collaborative research and educational initiatives. The UChicago faculty advisory committee is led by Neil Shubin, the Robert R. Bensley Professor of Organismal Biology and Anatomy and Senior Advisor to the President and Vice President for Research and National Laboratories at the University of Chicago.

“There is a clear need for focused conferences on imaging, computation, marine resources, and other scientific priorities, with white papers as output. These will begin in fall 2014,” Shubin said as the retreat drew to a close. The MBL and UChicago faculty advisory committees will also start examining the scientific infrastructure at the institutions, he said. “What do we have, and what do we need to move forward in our collaborations?”

Welcome to the MBL

The second retreat also served as a welcoming orientation for many UChicago and Argonne faculty who had never visited the MBL before. Tours of the Loeb teaching labs, the National Xenopus Resource, the visiting scientists’ labs in Rowe, and the Marine Resources Center were offered, and a poster session and mixer launched the retreat on Friday night.

“These kind of visits leave people energized and transformed, when they see the resources that the affiliation brings to the table. Both Neil Shubin and I want to encourage more of them,” Gitlin said. To that end, the University of Chicago has set up an MBL-UChicago Connection Fund that enables visits between the campuses for students, scientists and staff, as well as joint workshops.

“Enormous Potential”

En route to achieving broad consensus on scientific themes that the affiliates could address, the retreat yielded an abundance of stimulating ideas for scientific exchange. Ideas flowed both from the breakout group discussions and from scientific talks (see retreat program).

For example, “how to deal with questions of scale across the sciences” emerged as an important question that the affiliates could effectively investigate, said MBL President and Director Joan Ruderman. “We have an opportunity to look in a large way from genomes to global cycles,” she said. “Also, we are also are just starting to explore marine diversity, from the microbes that are estimated to be more numerous than stars in the universe, to marine organisms that may serve as good models for biomedical discovery,” she said. “There is enormous room for discovery here, and opportunities for translation into improved public health and for stewardship of the Earth for all future life.”