Arkhipova Lab

Irina Arkhipova
Associate Scientist                                                                                              
e: iarkhipova@mbl.edu
p: 508 289 7120
f: 508 457 4727
Arkhipova_CV

Dr. Irina Arkhipova is a molecular evolutionary geneticist who is interested in the role of mobile genetic elements in eukaryotic genome structure, function and evolution. She studies the genomes of bdelloid rotifers, tiny aquatic invertebrates best known for their long-term asexuality and the ability to withstand frequent cycles of desiccation and rehydration at any life stage. She discovered that bdelloid genomes contain massive amounts of foreign DNA horizontally transferred from sources as diverse as bacteria, fungi, protists, and plants. She also discovered a novel class of intron-containing retroelements that may play a role in telomere maintenance, share a common ancestor with telomerase reverse transcriptases, and can be variably organized in mobile units displaying huge size variations. The main research directions in her lab include elucidation of the role of reverse transcriptase-related cellular genes, involvement of RNA-mediated silencing pathways in genome defense and genome integrity, functional studies of horizontally transferred genes and giant retrotransposons, and comparative genomic and epigenomic studies with the emphasis on transposable elements, which are often pursued in collaboration with other labs worldwide. Research in the lab is expanded into fungal or bacterial model systems when they provide better molecular tools for addressing the basic questions that initially emerge from rotifer studies. She is a leading expert on transposable elements, which she studied since her undergraduate years. She published over 70 papers on this topic, including articles in high-profile journals such as Science, Cell, Nature, Genetics, and PNAS, contributed chapters to books from Wiley, McGraw Hill, Karger AG and World Scientific, and co-authored a book “Drosophila Retrotransposons” for Landes/Springer. She serves as an expert on multiple national and international advisory panels, as an Associate Editor of Molecular Biology and Evolution, and as the Editor-in-Chief of Mobile DNA, the flagship journal in the field.
Dr. Arkhipova received her B.S./M.S in Biochemistry from Moscow State University, and her Ph.D. in Molecular Biology from the Engelhardt Institute of Molecular Biology in Moscow, Russia, where she first elucidated the replication mechanism of LTR retrotransposons. She received post-doctoral training at the University of Edinburgh in the UK as a Wellcome Trust Fellow, and then moved to the US to become a post-doctoral researcher and then a staff scientist at Harvard University in the laboratory of Prof. Matthew Meselson, where she continued her work on transposable elements. She joined the faculty at the MBL as an Assistant Research Scientist, and was subsequently promoted to Assistant and then to Associate Scientist. She is also an Associate Professor in the Department of Molecular Biology, Cell Biology and Biochemistry at Brown University, and is a member of the MCB Graduate Program at Brown. She is one of the founding members of the Mobile Genetic Element Cluster at the MBL, and has been organizing a bi-annual regional meeting on mobile genetic elements since 2007 (schedules can be found at the link below).

Mobile Genetic Element Cluster

 

Personnel


Fernando Rodriguez
Research Scientist
e: frodriguez@mbl.edu
p: 508 289 7510
f: 508 457 4727
Rodriguez_CV2014


Irina Yushenova
Research Scientist
e: iyushenova@mbl.edu
p: 508 289 7146
f: 508 457 4727
Yushenova_CV

Lab Photos Summer 2017

L_to_R: Fernando Rodriguez, Research Scientist; Irina Yushenova, Research Scientist; Brandon M. Lê, REU summer intern, Brown University; Katherine Dunham, Brown-MBL LINK summer intern; Jonathan Dow, Brown-MBL Rosenthal LINK summer intern; Laura Swain, Metcalf summer intern, University of Chicago

 

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