Eugene Bell Center for Regenerative Biology and Tissue Engineering

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The Eugene Bell Center for Regenerative Biology and Tissue Engineering was established in 2010 through the extraordinary leadership gifts of Millicent Bell and John and Valerie Rowe. Research in the Bell Center is intended to elucidate the molecular, genetic and cellular mechanisms underlying the growth and replacement of highly differentiated tissues during development, physiological turnover and repair following injury. These processes are critical to human health and biology and have been the focus of elegant studies in a myriad of model organisms at the Laboratory since the pioneering work of MBL scientists Thomas Hunt Morgan and Jacques Loeb.

Utilizing unique and highly tractable marine and aquatic model organisms, high throughput and comparative genetic approaches, novel imaging technologies and the latest advances in data-intensive computational analysis, scientists in the Bell Center, in collaboration with colleagues at the University of Chicago and the Argonne National Laboratory, are providing answers to some of the most fundamental and intriguing questions in biology. From the control of cellular energetics to the processes of organ development and spinal cord regeneration these transformative discoveries are allowing new insights into the basic mechanisms of tissue growth, repair and regeneration in all metazoans and will permit novel approaches to the understanding, treatment and prevention of human disease.

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Recent Publications

Wühr M1, Freeman Jr. RM1, Presler M, Horb ME, Peshkin L, Gygi SP, Kirschner MW (2014) Deep Proteomics of the Xenopus laevis Egg using an mRNA-Derived Reference Database. Curr. Biol. 24: 1467–1475, DOI: 10.1016/j.cub.2014.05.04

Chowanadisai, W., Graham, D.M., Keen, C.L., Rucker R.B., Messerli, M.A. 2013A zinc transporter gene required for development of the nervous system. Commun. Int. Biol. 2013: 6:e26207

Graham, D.M., Huang, L. Robinson, K.R. and Messerli, M.A. 2013 Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. J. Cell Sci. 126:4602-4613.

Helm, R. R., Siebert, S., Tulin, S., Smith, J., Dunn, C. Characterization of differential transcript abundance through time during Nematostella vectensis development. BMC Genomics.14(1):266, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23601508

Hinaux, H., Poulain, J. Da Silva, C., Noirot, C., Jeffery, W. R., Casane, D., and S. Retaux, (2013). De novo sequencing of Astyanax mexicanus surface fish and Pachon cavefish transcriptomes reveals enrichment of mutations in putative cavefish eye genes. PLoS ONE 8(1): e53553. doi:10.1371/journal.pone.0053553.s

Lau BY, Fogerson SM, Walsh RB, Morgan J.R. Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury. Exp Neurol. 2013. Volume 250, December 2013, Pages 31–42. http://www.ncbi.nlm.nih.gov/pubmed/24041988