Gene Regulatory Networks for Development

Course Information

Course Date: October 14 – October 27, 2018

Deadline: July 20, 2018

2017 Syllabus (PDF)

Directors: Scott Barolo, University of Michigan; and Isabelle Peter, California Institute of Technology

Course Description

Gene regulatory networks (GRNs) are key to the genomic control of development in animals and plants. To study GRNs requires insights from various research fields, including systems biology, developmental and evolutionary biology, as well as functional genomics, and provides an integrative approach to fundamental research questions in biology. This course introduces the concepts of GRNs, and teaches experimental and computational methods used to study them, through highly interactive lectures, discussions, group projects, and practical tutorials. We will cover a broad range of topics, including transcriptional control systems, the structural organization of hierarchical networks, developmental functions of GRN circuit modules, GRN evolution, and computational modeling using BioTapestry as well as Boolean and quantitative mathematical approaches. Students will learn how to generate GRN models based on data extracted from the literature, and will generate computational models to analyze dynamic circuit behavior. We will present and discuss a broad range of experimental approaches and how they are effectively used for studying gene regulation and developmental GRNs. Examples of experimentally solved developmental GRNs from a variety of organisms, such as flies, sea urchins, frogs, chicken, and mice, will be explored. Students are encouraged to share their research projects in a poster session, and to discuss with course faculty how to apply the approaches taught in the course to their own research questions. The course is intended for advanced graduate students, postdoctoral scholars, and faculty.

2018 Course Faculty & Lecturers

Scott Barolo, University of Michigan
James Briscoe, The Francis Crick Institute, London
Fernando Casares, Andalusian Center for Developmental Biology, Spain
Ken Cho, University of California, Irvine
Doug Erwin, Smithsonian Institution
Robb Krumlauf, Stowers Institute
Bill Longabaugh, Institute for Systems Biology, Seattle
Lee Niswander, University of Colorado, Denver
Isabelle Peter, Caltech
John Reinitz, University of Chicago
Ellen Rothenberg, Caltech
Trevor Siggers, Boston University

Course Sponsors

This course is supported with funds provided by:
Howard Hughes Medical Institute
NIH / National Institute of Child Health & Human Development
Society for Developmental Biology