Zebrafish Development and Genetics

Course Information

Course Date: August 4 – August 18, 2018

Deadline: April 16, 2018 | Apply here

Course Website

2017 Schedule

Directors: Sharon Amacher, The Ohio State University; and Deborah Yelon, University of California/San Diego

Course Description

Over the past 20 years, the zebrafish has emerged as a powerful model system for the study of vertebrate development and disease. This intensive two-week course for advanced graduate students, postdoctoral fellows, and independent investigators will focus on the development and genetics of zebrafish. The course will cover time proven as well as novel technologies geared towards their application in zebrafish. Mornings and afternoons will be devoted mainly to laboratory exercises and the evenings to lectures and discussion. Limited to 22 students.

Lectures and labs in the first week will introduce students to early development of the zebrafish and to methods for manipulating and studying gene function, including genetic and small molecule screening, mRNA overexpression, optogenetics, and functional knockdown approaches. In addition, students will gain experience in relevant bioinformatics tools, cell fate mapping, regeneration experiments, and mounting and imaging of antibody and in situ samples for publication ready documentation. In the second week, students will be introduced to imaging of live cells and intracellular signaling events, biophysical manipulations, cell transplantation/chimera analysis, and behavioral testing of live animals. Informal ‘roundtable’ discussions held periodically during the course include topics such as reverse genetics, transgenesis, and zebrafish breeding and husbandry.

Each laboratory exercise will be under the supervision of a senior faculty member who will be assisted by one or two junior faculty members. Senior faculty will give research lectures about their work, in addition to leading discussions on topics covered in the course.

2017 Course Faculty & Lecturers

Sharon Amacher, Ohio State University
Jon Clarke, Kings College London
Andres Collazo, CalTech
Elena Dreosti, University College London
Jim Fadool, Florida State
Steven Farber, Carneige Institute (Johns Hopkins)
Antonio Giraldez, Yale University
Marcos Gonzalez-Gaitan, University of Geneva
Michael Granato, Upenn
Corinne Houart, Kings College London
Anna Huttenlocher, University of Wisconsin, Madison
Cecilia Moens, Fred Hutchinson
Mary Mullins, UPenn
Kenneth Poss, Duke University
David Raible, University of Washington, Seattle
Erez Raz, University of Münster
Alex S Schier, Harvard University
Lila Solnica-Krezel, Washington University, St. Louis
Steve Wilson, University College London
Deborah Yelon, University California at San Diego

Course Support

This course is supported with funds and equipment provided by:
Howard Hughes Medical Institute
National Institute of Neurological Disorders and Stroke
National Institute on Deafness and Other Communication Disorders
National Institute of Mental Health
National Institute on Drug Abuse
National Institute of Child Health and Human Development