Research in the lab is focused on understanding endoderm and pancreas development as well as developing genome editing technologies in Xenopus. The endoderm and pancreas work is geared toward elucidating the molecular signals underlying specification of the pancreas. The lab uses the amphibian, Xenopus laevis and Xenopus tropicalis, as the model organisms to identify the molecular network controlling endodermal organ development. The main projects in the lab are:
1) To define in detail the molecular lineage of the beta cell pathway from endocrine progenitors
2) Elucidate how endodermal progenitor cells regulate proliferation and differentiation.
3) Develop and enhance genome editing technologies in Xenopus and create mutants to model human disease.
Dr. Marko Horb
Director, National Xenopus Resource
7 MBL Street
Woods Hole, MA