How Scientists Engineered A See-through Squid with its Brain in Plain View | WBUR

The hummingbird bobtail squid (Euprymna berryi). Ahuja et al. engineered the albino, on left, by deactivating two pigmentation genes. The wild type is on the right. Credit Carrie Albertin and MBL Cephalopod Program

This story aired throughout the country on NPR's "All Things Considered."

Becoming invisible usually requires magic.

For some thumb-sized squid, though, all it takes is a little genetic tweaking.

Once these squid are genetically altered, "they're really hard to spot," even for their caretakers, says Joshua Rosenthal, a senior scientist at the Marine Biological Laboratory in Woods Hole, Mass.

"We know we put it in this aquarium, but they might look for a half hour before they can actually see it," Rosenthal says. "They're that transparent."

The see-through squid are offering scientists a new way to study the biology of a creature that is intact and moving freely.

"It changes the way you interpret what's going on in this animal," says Caroline Albertin, a fellow at the lab. "You can look through and see their three hearts beating, you can see their brain."

The transparent squid is a genetically altered version of the hummingbird bobtail squid, a species usually found in the tropical waters from Indonesia to China and Japan. It's typically smaller than a thumb and shaped like a dumpling. And like other cephalopods, it has a relatively large and sophisticated brain. Read the full story on WBUR.

Source: How Scientists Engineered A See-through Squid with its Brain in Plain View | WBUR