Central Microscopy Facility (CMF)
In addition to serving MBL resident researchers, the CMF is a fee-for-use facility designed to provide researchers, regional industry, and academic partners access to state-of-the-art instrumentation and expertise. The CMF provides access, training and assistance with a wide array of high-end imaging systems, as well as powerful computer workstations for image post-processing.
Imagine being able to reconstruct a sample in 3D on a SEM! With the generous support of the Massachusetts Life Sciences Center (MLSC), the MBL has acquired a ThermoFisher Helios 5 Hydra PFIB-SEM (plasma focused ion beam-scanning electron microscope) with cryo stage and Oxford EDS/EBSD and a Leica Stellaris 8 STED confocal super resolution microscope to enable correlative microscopy capabilities. These advanced imaging capabilities, coming soon to the MBL, will provide new views and better resolution of biological and material samples.
Light Microscopy (including confocal and lightsheet)
State-of-the-art optical microscopy equipment for techniques such as phase, darkfield, fluorescence, polarization, DIC, confocal and lightsheet are available. See the CMF Equipment page for detailed information on the specific microscopes. All instruments are equipped with digital cameras and PC based operating software. Various vendors provide seasonal loan of instruments and accessories.
Services are based on a JEOL 200CX transmission electron microscope and a Zeiss Supra40VP scanning electron microscope (with array tomography system, cryo stage and EDS/EBSD analysis system), supported by preparative and ancillary equipment such as ultramicrotomes, sputter coaters, etc. A Leica ICE high pressure freezer is available.
Our Image Analysis Lab provides high-performance computer workstations with commercial software such as Imaris, Aivia, Arivis, and MATLAB.
Wide-ranging preparative equipment is available including several microtomes - a cryostat, paraffin microtomes, a vibratome and ultramicrotomes. The facility also provides liquid nitrogen for purchase.
Service and Training
We provide consultation on appropriate experimental design, technical instruction, and operational assistance for our instruments. This may be useful to individuals planning a project but who have limited knowledge of the appropriate technique.
For general CMF inquiries:
For a complete list of services and prices, and to inquire about requests for specific instrumentation contact:
Director, Imaging Services; Staff Scientist
Tel: (508) 289-7273