Gene Regulatory Networks for Development

Course Information

Watch the GERN WebinarCourse Date: October 10 – October 23, 2021

Deadline: July 15, 2021

2019 Syllabus

Directors: Scott Barolo, University of Michigan; and Isabelle Peter, California Institute of Technology

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Course Description

Gene regulatory networks (GRNs) are key to the genomic control of development in animals and plants. To study GRNs requires insights from various research fields, including systems biology, developmental and evolutionary biology, as well as functional genomics, and provides an integrative approach to fundamental research questions in biology. This course introduces the concepts of GRNs, and teaches experimental and computational methods used to study them, through highly interactive lectures, discussions, group projects, and practical tutorials. We will cover a broad range of topics, including transcriptional control systems, the structural organization of hierarchical networks, developmental functions of GRN circuit modules, GRN evolution, and computational modeling using BioTapestry as well as Boolean and quantitative mathematical approaches. Students will learn how to generate GRN models based on data extracted from the literature, and will generate computational models to analyze dynamic circuit behavior. We will present and discuss a broad range of experimental approaches and how they are effectively used for studying gene regulation and developmental GRNs. Examples of experimentally solved developmental GRNs from a variety of organisms, such as flies, sea urchins, frogs, chicken, and mice, will be explored. Students are encouraged to share their research projects in a poster session, and to discuss with course faculty how to apply the approaches taught in the course to their own research questions. The course is intended for advanced graduate students, postdoctoral scholars, and faculty.

Financial Information: Tuition: $1,700; Room & Board: $1,053* (*Actual costs may be greater based on number of nights of occupancy). The admissions process at the Marine Biological Laboratory is need-blind, meaning that we evaluate students on their merits alone, without weighing their financial situations. Financial assistance will be considered for those admitted students who are in need. Upon acceptance, students will be asked to complete a financial aid request form if they need assistance.

In 2019, 100% of those students in the Gene Regulatory Networks for Development course who requested financial aid received some support. The amount of financial aid available from the MBL varies by course based on funding from grants and scholarships, but typically covers 70-100% of student need.

2019 Course Faculty & Lecturers

Scott Barolo, University of Michigan Medical School
Isabelle Peter, California Institute of Technology
James Briscoe, The Francis Crick Institute
Martha Bulyk, Harvard
Ken Cho, University of California, Irvine
Doug Erwin, Smithsonian Institution
Robb Krumlauf, Stowers Institute
Arthur Lander, University of California, Irvine
Bill Longabaugh, Institute for Systems Biology
Lee Niswander, University of Colorado Boulder
Alexander Stark, IMP Vienna
Zeba Wunderlich, University of California, Irvine

Course Sponsors

This course is supported with funds provided by:
Howard Hughes Medical Institute
NIH / National Institute of Child Health & Human Development
Society for Developmental Biology