Emeritus Senior Scientist
- ORCID ID:
B.S., Biochemistry (cum laude), University of Pittsburgh, 1974
Jonathan Gitlin is an American pediatrician specializing in early human development and genetics and recognized for his research in human nutrition. Prior to joining the MBL, he was on the faculty at Harvard Medical School, Washington University School of Medicine and Vanderbilt University where he was the James C. Overall Professor & Chair of the Department of Pediatrics. He is currently a Senior Scientist Emeritus at Marine Biological Laboratory, where he served as both the Director of the Eugene Bell Center and as Director of Research. Dr. Gitlin is the author of more than 150 papers and has received numerous professional honors. He is an elected fellow of the AAAS and a member of the National Academy of Medicine.
Research efforts in the laboratory have focused on the interplay of the environment and the genome in early human development as a model for understanding human disease, environmental adaptation and evolutionary biodiversity.
Elucidation of the genetic basis of the disorders of human copper metabolism revealed the evolutionarily conserved mechanisms of copper trafficking and compartmentalization within cells and defined the unique role of copper in synaptic plasticity and neuronal injury. Similarly, genetic studies of iron metabolism in our lab revealed the essential physiologic role of ceruloplasmin in iron homeostasis and neuronal survival in the developing central nervous system. More recently, studies utilizing zebrafish as a model for early development revealed an evolutionarily conserved developmental hierarchy of copper metabolism that is informed by specific genetic factors, providing a novel paradigm for the role of suboptimal nutrition in the pathogenesis of human birth defects.
Current studies are focused on energy homeostasis during early development and the genetic basis for the biochemical adaptations to oxygen availability in extreme environments that are a fundamental aspect of evolutionary biology. (see Life Interrupted: Exploring the World of Extreme Adaptation)
Soma S, Latimer AJ, Chun H, Vicary AC, Timbalia SA, Boulet A, Rahn JJ, Chan SSL, Leary SC, Kim BE, Gitlin JD, Gohil VM. Elesclomol restores mitochondrial function in genetics models of copper deficiency. Proc Natl Acad Sci 2018; 11: 8161-8166. PMCID: PMC6094114
Kumar D, Thomason RT, Yankova M, Gitlin JD, Mains RE, Eipper BA, King SM. Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme. Sci Rep 2018: 8:4547. PMCID: PMC5852006
Copper homeostasis: specialized functions of the late secretory pathway. Dev Cell 2014; 29:631-632. DOI: 10.1016/j.devcel.2014.06.002
Wang Y, Zhu S, Weisman GA, Gitlin JD, Petris MJ. Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis. PloS One 2012; 7:e43039. PMCID: PMC3416770
van Boxtel AL, Gansner JM, Hakvoort HWJ, Snell H, Legler J, Gitlin JD. Lysyl oxidase like 3b is critical for cartilage maturation during zebrafish craniofacial development. Matrix Biology 2011; 30:178-187. PMCID: PMC3089694
Mendelsohn BA, Kassebaum BL, Gitlin JD. The zebrafish embryo as a dynamic model of anoxia tolerance. Dev Dyn 2008; 237:1780-1788. PMCID: PMC3081722
Thiele DJ, Gitlin JD. Transition Metal Metabolism: Assembling the Pieces. Nature Chem Biol 2008; 4:145-147. PMCID: PMC3459349
Madsen EC, Morcos PA, Mendelsohn BA, Gitlin JD. In vivo correction of a Menkes disease Madsen EC, Morcos PA, Mendelsohn BA, Gitlin JD. Proc Natl Acad Sci 2008; 105; 3909-3914. PMCID: PMC2268804
Madsen E, Gitlin JD. Copper and Iron Disorders of the Brain. Annual Review Neuroscience 2007; 30:317-337. DOI:10.1146/annurev.neuro.30.051606.094232
Mendelsohn BA, Yin C, Johnson SL, Wilm T, Solnica-Krezel L, Gitlin JD. Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metabolism 2006; 4:155-162. DOI: 10.1016/j.cmet.2006.05.001