Senior Scientist and Director, Bell Center
- ORCID ID:
B.S. with Honors, Biology, The University of North Carolina at Chapel Hill, 1995
The laboratory of Dr. Jennifer Morgan studies the cellular and molecular mechanisms by which neurons communicate with each other at synapses, a process called synaptic transmission. We study mechanisms of normal synaptic transmission, as well as how neurotransmission is impacted by spinal cord injury and disease. One ongoing project involves identifying how synapses are deleteriously affected by Parkinson's disease, and we are currently developing strategies to slow or reverse disease-associated synaptic dysfunction. Another project is focused on understanding how neurotransmission can be restored after spinal cord injury by regenerative processes, such as axon and synapse regrowth, or other forms of neural plasticity. Ultimately, we want to understand how these regenerative processes contribute to restoring normal behaviors after injury and how to improve functional outcomes.
For these projects, we use sea lampreys (Petromyzon marinus) as our model organism. Lampreys are cyclostomes, which are the most basal extant group of vertebrates. Lampreys possess a subset of very large neurons that can be identified across animals, the giant reticulospinal (RS) neurons, which provides several advantages for our studies. First, as the name indicates, these RS neurons are giant! They have especially large axons (20-80 microns) and synapses (1-2 microns), which are easily an order of magnitude larger than in most vertebrate models. Second, these giant neurons are experimentally tractable and amenable to molecular manipulations both in the normal and regenerating state. To approach our questions, we utilize a variety of technical approaches including, candidate gene and transcriptome analyses, molecular perturbations, biochemistry, fluorescence imaging, histology, electron microscopy, electrophysiology, and behavior.
Katz HR, Arcese AA, Bloom O, Morgan JR (2022) Activating transcription factor 3 (ATF3) is a highly-conserved pro-regenerative transcription factor in the vertebrate nervous system. Frontiers in Cell and Developmental Biology.10:824036. doi: 10.3389/fcell.2022.824036.
Fouke KE, Wegman ME, Weber SA, Brady EB, Román-Vendrell C, Morgan JR (2021) Synuclein regulates synaptic vesicle clustering and docking at a vertebrate synapse. Frontiers in Cell and Developmental Biology. 9:774650. doi: 10.3389/fcell.2021.774650.
Fies J, Gemmell BJ, Fogerson SM, Morgan JR, Tytell E, Colin SP (2021) Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration. Journal of Experimental Biology. jeb.242639. doi: 10.1242/jeb.242639.
Haspel G, Severi KE, Fauci LJ, Cohen N, Tytell ED, Morgan JR (2021) Resilience of neural networks for locomotion. Journal of Physiology. doi: 10.1113/JP279214.
Román-Vendrell C, Medeiros AT, Sanderson JB, Jiang H, Bartels T, Morgan JR (2021) Effects of excess brain-derived human a-synuclein on synaptic vesicle trafficking. Frontiers in Neuroscience. 15:639414 doi: 10.3389/fnins.2021.639414.
Katz HR, Fouke KE, Losurdo NA*, Morgan JR (2020) Recovery of burrowing behavior after spinal cord injury in the larval sea lamprey. Biological Bulletin. December 2020. doi/10.1086/711365.
Soll L, Eisen JN, Vargas KJ, Medeiros AT, Hammar KM, Morgan JR (2020) a-Synuclein-112 impairs synaptic vesicle recycling consistent with enhanced membrane binding properties. Frontiers in Cell and Developmental Biology. 8:405. doi: 10.3389/fcell.2020.00405.
Banks SML*, Medeiros AT*, McQuillan M, Wang L, Ibarraran-Viniegra AS, Busch DJ, Sousa R, Lafer EM, Morgan JR. (2020) Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses. eNeuro 7(1). pii: ENEURO.0448-19.2020. doi: 10.1523/ENEURO.0448-19.2020. (* equal contributors)
Chanaday N, Cousin M, Milosevic I, Watanabe S, Morgan JR (2019) The synaptic vesicle cycle revisited: new insights into the modes and mechanisms. Journal of Neuroscience. 39:8209-8216. https://doi.org/10.1523/JNEUROSCI.1158-19.2019.
Hanslik K, Allen SR, Fogerson SM, Harkenrider T, Guadarrama E, Morgan JR. (2019) Behavioral and functional recovery in the sea lamprey after spinal cord re-transection. PLoS One. 14(1):e0204193. doi: 10.1371/journal.pone.0204193. (Featured in Nature: Research Highlights Feb. 6, 2019)
Herman PE, Papatheodorou A, Bryant SA, Waterbury CKM, Herdy JR, Arcese AA, Buxbaum JD, Smith JJ, Morgan JR*, Bloom O*. (2018) Highly conserved molecular pathways, including Wnt signaling, promote functional recovery from spinal cord injury in lampreys. Scientific Reports. 8:742. doi: 10.1038/s41598-017-18757-1. PMID: 29335507. (* co-corresponding)
Medeiros AT, Soll LG, Tessari I, Bubacco L, Morgan JR. (2017) a-Synuclein dimers impair vesicle fission during clathrin-mediated synaptic vesicle recycling. Frontiers in Cellular Neuroscience. 11:388. doi: 10.3389/fncel.2017.00388. PMID: 29321725.
Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SML, Klarner F-G, Schrader T, Bitan G, Morgan JR. (2016) Reducing synuclein accumulation improves neuronal survival after spinal cord injury. Experimental Neurology. 278:105-115.
Busch DJ, Oliphint PA, Walsh RB, Banks SML, Woods WS, George JM, Morgan JR (2014) Acute increase of a-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation. Molecular Biology of the Cell. 25:3926-3941. (With cover illustration). PMID: 25273557.
Lau BYB, Fogerson SM, Walsh RB, and Morgan JR. (2013) Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury. Experimental Neurology. 250: 31-42. PMID: 24041988.
Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanadam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SMJ, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson Y-W, Nanlohy KG, Libants SV, Yeh C-Y, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner M, Warren WC, Clifton SW, Wilson RK, Li W. (2013) Sequencing of the sea lamprey (Petromyzon marinus) provides insights into vertebrate evolution. Nature Genetics. 45:415-21. PMID: 23435085.
Busch DJ and Morgan JR (2012) Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury. Journal of Comparative Neurology. 520: 1751-1771. (Highlighted in BioTechniques 06/22/12). PMID: 22120153.